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When vasodilators are used in combination, an additive effect on blood pressure may be anticipated. In some patients, concomitant use of these two drug classes can lower blood pressure significantly [see Drug Interactions 7.
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In these 5 trials, tadalafil 5 mg, 10 mg, and 20 mg showed clinically meaningful and statistically significant improvements in all 3 primary efficacy variables see Tables 12, 13 and Study F a. In addition, there were improvements in EF domain scores, success rates based upon SEP Questions 2 and 3, and patient-reported improvement in erections across patients with ED of all degrees of disease severity while taking tadalafil, compared to patients on placebo. In this problems with erection, placebo-controlled, Sildenafil 50mg, double-blinded, parallel-arm design Viagra 100mg trial, tadalafil demonstrated clinically meaningful and statistically significant improvement in erectile function, as measured by the EF domain of the IIEF questionnaire and Questions 2 and 3 of the SEP diary s ee Table E ff i c acy Results in ED Patients following Radical Prostatectomy - Tadalafil was shown to be effective in treating patients who developed ED following bilateral nerve-sparing radical prostatectomy.
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